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Appendix IV: Treatment characteristics

YEAR FIRST AUTHOR JOURNAL Fibrinolytic Bolus dose Mean

continuous dose

(±SD or range)

 Mean

total dose

(±SD or range)

 Catheter used Infusion technique Mean

therapy duration (±SD or range)

 Additional interventions

<30 days

 Per procedural anticoagulation Post procedural anticoagulation Per procedural monitoring Level of care Hospital type Costs
1992 LeBlang J Vasc Interv Radiol UK NR 87,000 IU (50,000-150,000) 1,855,000 IU (±7,885) multiple side hole catheter, or coaxial infusion system continuous 20.4 hours (2-62) 75% percutaneous, 16% surgical heparin: side-port 100 U/h + systemic >700 U/h in 29 patients NR CBCC, platelet count, PT, APTT, fibrinogen once in 8 hours NR Private hospital NR
1992 Buckenham Eur J Vasc Surg rt-PA 3x 5 mg 0.05 mg/kg/hour 19 mg (15-26) single end hole 5.0 Fr continuous 109 min (30-240) 55% angioplasties, 15% surgical none 20,000 IU heparin intravenously in 24h NR NR General teaching hospital NR
1991 Goffette Acta Radiologica UK 75,000-375,000 UK 75,000 IU/hour NR coaxial catheter, 0.9 mm open end guidewire continuous 32 hours PTA: 33% Heparin systemic 15,000 IU/24h NR angiography NR General hospital NR
1991 Berridge Br J Surg rt-PA none 0.5 mg/h NR 4 or 5 Fr Gauge catheter straight or sidewinder type continuous 35 hours (14-64) 10% surgical (2) 250 IU heparin 1,000 U/h in 2 times 12 h Full clotting screen, platelet count, HB, whitecell count, urea, electrolyte estimation NR Academic hospital NR
1991 Parent J Cardiovasc Surg (Torino) UK 50,000-500,000 IU 20,000-80,000 IU/hour 2,525,000 IU 3-5.5 Fr polyethylelene end hole continuous 3.2 days 22.5% percutaneous, 25% surgical heparin 400-1,000 IU/h coaxial sheath/intravenously NR fibrinogen, APTT, PT, ht ICU Academic hospital average treatment costs $8,295
1991 McNamara Circulation UK 4000 IU/min 60,000-240,000 IU/hour NR transcatheter continuous 18 hours 22.2% surgical. 50% PTA (31 only PTA, 5 PTA and surgical) heparine 1,000 IU/h intravenous (97%) NR aPTT, fibrinogen, hemoglobin, platelets, fibrin degradation products, euglobulin lysis, and creatinine. Intensive care Academic hospital NR
1991 Sullivan Circulation UK 30,000-250,000 IU 60,000-240,000 IU/hour NR NR continuous NR 18,9 % surgical NR NR prothrombin time, activated partial thromboplastin time, hemo- globin, hematocrit, and platelets Intensive care or radiology department Academic hospital NR
1991 Cragg Radiology UK 50,000 IU or 250,000 IU 50,000U/hr or 125,000/hour 2,299,400 U 5 Fr infusion catheter continuous 20.4 hours 33,3 %PTA, 41,2 % surgical (10 bypass grafts, 1 endarterectomy, 10 bypass revision, 6 redo bypass) heparine NR fibrinogen, hemoglobine, aPTT, platelet count,mental status NR Academic hospital NR
1991 Gaston Kans Med UK NR 60,000-120,000U/hour NR 5 Fr straight non-side port cathether continuous NR 13% surgical (embolectomie), PTA heparine 5,000 IU + systemic 1,000 IU/h NR vital signs, doppler pulses and puncture sites Intensive care General teaching hospital NR
1990 Meyerovitz Radiology rt-PA, UK bolus rt-PA: 10mg, UK: 60,000 IU rt-PA 5 mg/hour, UK: 60,000-240,000 IU/hour NR NR continuous NR PTA: 25%, surgical: 53% NR NR NR NR Academic hospital NR
1990 Berridge Br J Surg t-PA 0.5 mg/hour NR NR 4 or5 Fr intra-arterial catheter continuous 29 hours (±16) 53 % PTA, 7.1% surgical (1 fempop graft, 1 amputation) Heparine: 250 IU/hour (n=15) NR TCT, INR, aPTT, plasminogen, alfa-2-antiplasmine Ward Academic hospital NR
1989 Earnshaw Ann Vasc Surg t-PA 0.25-2.5 mg/hour NR NR NR continuous NR none NR plasma fibrinogen, fibrinogen degradation product, trombin clotting times Ward Academic hospital NR
1989 Hirshberg J Vasc Surg UK NR 20,000 IU/hour NR NR continuous 48 hours NR Heparine: 100 IU/h, systemic NR vital signs, limb observation, fibrinogen, aPTT, blood count NR Academic hospital NR
1989 Durham Radiology UK NR 100,000 IU/hour NR 5-or 6F catheter continuous 20 hours (1-66) 66% (PTA 22,6% and surgical 62,3%) Heparine heparine (46 cases) and conversion to warfarin in 3 cases NR Intensive care General teaching hospital NR
1989 Sullivan Radiology UK low dose: 52,000 IU, high dose 230,000 IU NR NR 5-or 6.5F catheter continuous Low dose: 33.6 hours (±17.6), High dose: 10.4 hours (±8.1) 3.4% surgical (embolectomy) Heparine: bolus 5,000 IU, continuous 800-1,000 IU/h NR Hb, Ht, aPTT NR Academic hospital NR
1986 Risius Radiology rt-PA NR 0.1 mg/kg/hour 29.5 mg (4.5-58) NR continuous 3.6 hours (1-6.5) 43.5% (surgical revision graft, endarteriectmie, bypass); 8.7% PTA none NR chemistry profile, urinalysis, complete blood count, protombin time, aPTT, trombin time, plasma fibrinogen, plasmingen, alfa2-antiplasmine NR Private hospital NR
1988 Earnshaw Br J Surg t-PA 0.25mg/h, 0.5 mg/h, 1mg/h, 2.5 mg/h 0.25mg/h, 0.5 mg/h, 1mg/h, 2.5 mg/hour NR NR continuous 22 hours 52.2 % PTA (12), 8.6% surgical ( 2; graft thrombectomy, sympathectomy) none warfarin or aspirin 300 mg/day with dipyridamole 100 mg/day aPTT,fibrinogen, fibrin degradation products, plasminogen, alfa2-antiplasmin levels and euglobin lysis times Ward Academic hospital NR
1987 Fiessinger Int Angiol UK NR 1,000 IU/kg/hour NR 4Fr or 5Fr Polyethylene catheter continuous 9.5 hours (4-20) NR 7.5 mg lys-plasminogen bolus NR NR NR Academic hospital
1995 Braithwaite Br J Surg t-PA NR NR NR NR NR NR NR NR aspirin NR NR General hospital NR
1995 Braithwaite Clin Radiol t-PA 10mg 2.5-3.5 mg/hour NR 4 or 5FR end hole catheter bolus 3 times 7 hours (1-3) 14% PTA, 9.3% surgocal (1fem-tib bypass, 1 excision false aneurysm, 2 amputations) only with PTA, 5,000 IU heparin aspirin or warfarin NR NR General hospital NR
1995 Hicken Can J Surg UK 250,000 IU 120,000 IU/hour NR infusion catheter continuous 24 hours (1-63) 12% PTA, 24% Surgical (4 bypasses, 1 valbve excision, 1 trombectomy) Heparin 1,000 IU/h NR NR Intensive care Academic hospital $2,930 per patient
1995 Huettl Radiology UK 206,600 IU NR 1,980,000 IU (250,000-5,700,00) NR continuous NR 13,3 % surigical (3 embolectomy, 3 bypasses) , further NR heparin IV NR NR NR mixed NR
1995 Bero J Vasc Interv Radiol rt-PA none 2 mg/hour 38.9 mg (8-84 mg) infusion catheter continuous 19.7 hours (4-42) NR Heparin IV 500-1,000 IU/h NR PTT, angiograms Intensive care or intermediate care unit mixed NR
1995 Chalmers Cardiovasc Surg UK low dose: 50,000 IU; high dose: 250,000 IU 50,000 IU/h or 125,000 IU/hour NR 5 Fr catheter continuous NR 54% surgical, 12.6% PTA heparin IV NR fibrinogen level, platelet count, hemoglobin, aPTT NR Academic hospital NR
1994 Hye J Vasc Surg UK 250,000 IU 60,000-120,000 IU/hour Pulse spray 670,000 IU . Pulse spray and infusion 1,230,000 IU NR continuous pulse spray: 118 minutes. continuous: 13,5 hours 64.5% PTA, 37.5% surgical heparin 5,000 IU + 1,000 IU/h Warfarin (87%) NR NR mixed NR
1994 Ouriel Radiology UK none 240,000 IU/hour for 2 hours, 120,000 IU/hour for 2 hours, 60,000 IU/hour rest of infusion NR NR continuous NR 67% surpery, 33 % PTA NR aspirin NR NR Academic hospital NR
1994 Varga J Vasc Surg NR NR NR NR NR NR NR NR NR NR NR NR mixed NR
1994 Ward Arch Surg. rt-PA A: none, B: bolus 20 mg 1 mg/hour A: 25mg, B: 31 mg 5 Fr cathter continuous A: 26.7 hours (±9.4), B: 14.4 hours (±7.9) PTA: 35.5 %, surgical: 26.7% Groep B: heparin 200 IU/h NR Hb, Ht and coagulation profile Intensive care General hospital NR
1994 STILE Investigators Ann Surg rt-PA, UK UK: bolus 250,000 IU rt-Pa: 0.1/0.05 mg/kg/hr, 2,000-4,000 IU/min NR infusion catheter continuous NR NR Heparin: systemic, bolus 5,000 IU, 1,000 IU/h (UK group) NR chest X-ray, ECG’s, VBB. fibrogeen, Pt en aPTT radiologie, cardiologie cathetrisatie setting of Intensive care General hospital NR
1994 Faggioli J Vasc Surg UK 75,000-150,000 IU bolus 1,000-4,000 IU/min, 25,000-75,000 IU/h NR NR continuous 53.8 hours (±29) PTA: 4.5%. Surgical:49.3% (jump grafts,m troboembolectomies, surgical angioplasties, aorto-fem bypas, fem-pop, fem-distal bypass) Heparin NR NR NR Academic hospital NR
1993 Bull Acta Chir Belg rt-PA, UK 100,000 IU or 10 mg 60,000 IU/h or 1 mg/h UK:572,000 IU (300,000-1,000,000 IU). rt-PA: 20 mg (30-60) 3.6 F catheter continuous UK: 160 min(60-270min), rt-PA: 95 min (25-200min) PTA: 44.8% ), surgical: 55.3% heparin: 20,000 IU/day for 3 days aspirin NR NR General hospital NR
1994 Ouriel J Vasc Surg UK 4000 IU/min 1,000-2,000 IU/min NR infusion catheter continuous 35.6 hours (±2.1) PTA: 4%, surgical:  66.7% none heparin and warfarin NR NR Academic hospital $15,672 (vs surgery group $12,253)
1993 Enon Ann Vasc Surg UK 2500 IU/kg 2,500 IU/kg/hour NR 5 Fr catheter continuous 32 hours (12-60) PTA: 31.6%, surigical: 52.6% heparin: 1,000 IU/kg/12 hours NR clinical observations, fibrinogen levels. arteriograms radiology suite Academic hospital NR
1993 Kandarpa Radiology UK 2,500 IU 2,000-4,000 IU/min CI: 202,000 (105,000), PS: 170,000 (74,000) 5 Fr catheter pulse spray and continuous CI: 28 hours, PS: 20 hours PTA: 32%, surigcal: 20% heparin: bolus 3,000-5,000 IU, systemic 6,000-1,000 IU/hours NR NR NR Academic hospital NR
1993 Earnshaw Br J Surg t-PA 0.5 mg/hour NR NR NR continuous 22 hours PTA: 8.7%, Surgery: 39% none NR NR surgical Ward and radiology department General hospital NR
1993 Spengel Clin Investig rt-PA none 1-9.4 mg/hour 5.8 mg (1-17.8) NR continuous 1-2 hours 52% PTA. 2.2 % surgical (bypass) none NR GGT, SGOT, SGPT, LDH,hemoglobin, hematocrit, total protein, erythrocytes,leukocytes, thrombocytes, thrombin time,partial thrombin time, fibrinogen, c~2-antiplasmin,and thromboplastin time NR Academic hospital NR
1993 DeMaioribus J Vasc Surg UK 250,000 IU 60,000-240,000 IU/hour NR NR continuous 14 hours (2-26hours) PTA: 31,5%, surgical 49% none warfarin in 14% hourly evaluation of the peripheral pulses, enurologic changes, signs of distal tromboembolism, bleeding from punture site Intensive care unit Academic hospital NR
1995 Ikeda Int Surg UK 250,000-1,000,000 IU 4,000 IU/min NR 3,378,000U (900,000-11,1000,000) continuous 27.7 hours (0.25-96 hours) NR heparin 600-1,000IU/h NR hb, pT, aPTT, fibrinogen NR Academic hospital NR
1996 Ouriel J Vasc Surg rUK none 2,000/4,000/6,000 IU/hour for 4 hours, thereafter 2,000 IU/h 2,700,000 IU (220,000), 3,200,000 IU (220,000), 3,500,000 IU (210,000) NR continuous 22.1 (1.9) hours, 23.4 (1.8)hours, 22.3 (1.8) hours NR Heparin aspirin, warfarin NR NR Academic hospital NR
1996 Bhatnagar J Cardiovasc Surg (Torino) UK 250,000-1,000,000 IU 60,000-240,000 IU/hour 3,228,000 IU NR continuous 27 hours PTA: 28% Surgical: 18% Heparin aspirin or ddipyridamole or Coumadin pulses, neurlogical changes, signs of distal embolism and local bleeding, aPTT, pTT, platelet count, Hb, Creatm fibrinogen Intensive care unit Academic hospital NR
1995 Knorring Ann Chir Gynaecol t-PA NR NR bolus plus infusion: 90mg (30-150), pulse-spray: 35 mg(12-100) NR pulse spray and continuous bolus: 3.5 hours (1-7), pulsespray 1.5 hours (0.5-3) PTA: 81% Surgical: 12.3% none NR NR NR Academic hospital NR
1996 Hess Eur J Vasc Endovasc Surg rt-PA 2.5 mg/hour NR 2.97 mg (0.4-12.5) 5,6 of 7 Fr catheter end hole continuous 78 min (10-385) PTA: 57.6, surgical:3% heparin: 5,000IU aspirin NR NR General hospital NR
1996 Singh Int Angiol rt-PA 0.5 mg/hour NR NR NR continuous NR PTA: 93% in group 3 NR NR NR NR General hospital NR
1995 McNamara J Vasc Interv Radiol UK 4000 IU/min 60,000-240,000 IU/h NR transcatheter continuous NR PTA: 82%, surigical: 15.6% heparin NR aPTT, fibrinogen, hemoglobin, hemtocrit, platelets, creat and Kalium Intensive care unit, vascular Ward Academic hospital NR
1996 Schweizer Eur.J.Radiol. rt-PA, UK UK: none, rt-Pa: 5mg UK: 60,000 IU/hour, rt-Pa: 5 mg/hour UK: 50,000 IU. rt-PA: 15 mg 5 Fr end hole cathter continuous UK: 24h (6-72). rt-PA: 2h (1-4) NR Heparin Uk: 700 IU/h, rt-PA: 750 IU/h fenprocoumon, marcoumar INR, aPTT, PT, fibrinogen and Doppler pressures NR General hospital NR
1996 Duda J Vasc Interv Radiol UK UK: 240,000 IU/hour UK: 120,000 IU/hour NR NR continuous UK: 19.1 hours PTA: 65% surgical: 70% Heparin 1,000 IU/h NR NR Intensive care unit General hospital NR
1996 Braithwaite Br J Surg t-PA NR NR high dose: 30 mg (20-41), low dose 21 (12-33) NR continuous high dose: 5 h (2-21), low dose, 20h (3-27) PTA: 31.8%, surgical: 11.4% NR aspirin, warfarin NR Intensive care unit, surgical high dependecy Ward General hospital high dose 6,967 pounds, low dose 3,435 pounds
1997 Byrne Virginia medical quarterly UK 100,000-200,000 IU 80,000-100,000 IU/hour NR 5Fr catheter continuous NR PTA: 74%, Surgical: 12.3% Heparin NR PT, aPTT, Hb, Ht, fibrinogen, fibrin split products intensice care unit, internediate care unit General hospital Not reproted exactly. $3,500 pharmacological cost, nursing $1,000 per 24 hours
1997 Armon Br J Surg rt-PA none 0.24 mg/min, thereafter 0.5 mg/hour 18 mg (4-61) NR pulse spray and continuous 100 min (35-270) PTA: 71% Surgical:7% NR aspirin NR NR Academic hospital NR
1997 Braithwaite Br J Surg t-PA low dose: 0,5 mg/h-1mg/h. High dose: 3x 5mg 0.5-1 mg/hour NR 3-7Fr catheters continuous Low dose: 20 h (2-46), high dose 4 h (0.25-46) PTA: 35.5%, Surgical: 24.7% NR NR angiograms NR General hospital NR
1997 Payelle Ann Vasc Surg UK 500,000 – 750,000 5,000 IU/min 1,160,000 IU (±240,000) 5Fr catheter pulse spray and continuous 150 min (66) PTA: 63%, surigical: 17% heparin NR NR vascular radiology suite Academic hospital NR
1997 Spence AJR Am J Roentgenol UK 250,000 IU 60,000-120,000 IU/hour 2,590,000 IU (±1,200,00) infusion catheter continuous 27 hours (14) NR heparin NR NR NR Academic hospital NR
1997 Matas Ann Vasc Surg UK 4,400 IU/kg 4,400 IU/kg/hour 4,380,000U 5Fr catheter continuous 13.88 hours (1-24) PTA: 43%, surgical: 21% none NR ht, pT aPTT, platelets, fibrinogen, fibrin degraddation products NR General hospital NR
1997 Rickard Cardiovasc Surg UK 100,000-1,400,000 IU 10,000-20,000 IU/hour NR 5 or 6Fr catheter pulse spray and continuous NR PTA: 59%, surgical: 43% heparin NR aPTT intensive care unit General hospital AUD $2,440 excluding ICU and complications
1998 Braithwaite Br J Surg t-PA NR NR NR NR NR NR PTA: 19%, Surgical: 16% NR NR NR NR General hospital NR
1998 Ouriel N Engl J Med UK none 240,000 IU/h for 4 hours, thereafter 120,000 IU/h 3,500,000 IU (±110,000) NR not visible 24.4 (0.86) hours PTA: 47%, surgical: 70% not visible NR NR NR Academic hospital NR
1998 Wholey Cathet Cardiovasc Diagn UK 3-5 mg 1-2 mg/h NR 4 Fr catheter continuous 31 hours PTA: 19%, surgical: 36% heparin 400 IU/hour NR NR high dependency unit General hospital NR
1999 Lambert Eur J Vasc Endovasc Surg rt-PA 250,000 IU bolus 120,000 IU/hours NR NR continuous NR PTA: 33%, surgical: 19% Heprain 1,000 IU/hour NR repeat angiograms NR General hospital NR
1999 Suggs Am J Surg UK 250,000 IU bolus 120,000 IU/hours NR NR continuous NR PTA: 31.7%, surgical: 40% Heparin 1,000 IU/hour NR fibrinogem, aPTT NR mixed NR
1999 Ouriel J Vasc Interv Radiol UK 1: 2 mg ProUK, 2: 4 mg ProUK, 3: 8 mg ProUK, 4: 250,000IU bolus 1: 2 mg/hour, 2: 4 mg/hour, 3: 8 mg/hour, 4: 2,000-4,000 IU/min 1: 21 mg (0,60), 2: 37,3 mg (0.73), 3: 67.2 mg (1.83), 4: 2,500,000 IU (130,000) 5Fr cathter continuous 1: 16.7 (0,90) hours, 2: 15.4 (0.95) hours, 3: 12.7 (0.97) hours. PTA: 34%, surgical: 24% Heparin 2000 IU/hour NR NR NR Academic hospital NR
1999 Oguni Radiat Med UK 10,000-24,000 IU/min 10,000-20,000 IU/min 887,000 IU (240,000-1,680,000) 5Fr Catheter continuous NR PTA: 40%, surgical: 4% NR NR NR NR Academic hospital NR
2000 Kröger Angiology rt-PA none 2-10 mg in 3 hours, thereafter 1 mg/hour 29.5 mg (±23.9) NR continuous 2.8 days (±2.2) NR Heparin 15,000 IU NR NR NR Academic hospital NR
2000 Schweizer Angiology rt-PA NR 5 mg/hour NR 7Fr catheter continuous aspirin group: 110 min, abciximab: 75 min PTA: 18%, surgical:5% Heparin:5,000IUbolus, systemic 500 IU/hour pheprocoumon, aspirin NR NR Academic hospital NR
2001 Swischuk J Vasc Interv Radiol rt-PA NR NR 38.7 mg (6-120) 5Fr catheter continuous 27.9 hours (2-69hours) PTA: 71%, Surgical: 26% NR NR repeat angiograms NR Academic hospital NR
2001 Korn J Vasc Surg UK 250,000 IU 60,000-120,000 IU/hour NR 0.035 inch benson or glide wire continuous NR PTA: 63, surgical: 29% Heparin NR NR ICU Academic hospital for 100 cases: $18,490 ( 16,680-20,301)
2001 Haumer Thromb Res UK 250,000 IU 100,000 IU/hour NR 6Fr catheter continuous 16 (9-28) hours PTA: NR, Surgical: 12.9% Heparin 5,000IUbolus oral antocoagulation, aspirin NR angiography suite General hospital NR
2001 Duda Radiology UK 250,000 IU 2,000-4,000 IU/min 500,000 IU (250,000–2,250,000) multiside catheter continuous 120 min (60-440) PTA: 81%, surgical: 14% Heparin NR e platelet count; hematocrit, hemoglobin, and serum fibrinogen levels; activated partial thromboplastin time NR Academic hospital NR
2001 Schwierz Ann Vasc Surg UK none UK: 40,000-60,000 IU/hour, rtPA: 10 mg in 6 hours, thereafter 10 mg in 12 hours UK: 1,500,000 IU, rtPA 20mg NR continuous 30 hours (3-144) PTA: 20%, surgical: 24% Heparin 600-1,000IU /hour NR NR NR General hospital NR
2001 Mahler J Endovasc Ther rt-PA, UK rt-PA: 2.5 mg/h, UK: 100,000 IU/h NR Hess technique: rt-PA: 4.7 mg (3), UK: 138,000 IU (67,000), Schenider technique: rt-Pa 7.6 mg (3.2), UK: 271,000 IU (173,000) continuous Hess rtpa: 83.6 min (45.7), UK: 74.3 min (35.7). Schneider rtpa: 58.3 min (105.5), UK: 46.1 min (89.4) PTA: 55%, surgical: 12% Heparin: 5,000U bolus NR NR NR Academic hospital NR
2002 Castaneda J Vasc Interv Radiol rt-PA 0,5 U 1: 0,5 U/hr, 2: 0,25 U/hr, 3, 0,125 U/hr 1: 14,6 I U (7,12), 2: 7,42 IU (3,04) , 3: 5,27 IU (2,73) NR continuous 1: 29.22 hours (±14), 2: 29.68 hours (±12), 3: 42.16 hours (±22) PTA: 66%, surgical: 28% Heparin 400-500U/hr NR NR NR Academic hospital NR
2003 Nehler J Vasc Surg t-PA, UK none UK: 150,000-200,000 IU/hour, tPA: 0,05 mg/kg/hour NR NR continuous NR PTA: 29%, surgical: 38% Heparin NR NR NR Academic hospital NR
2003 Holten J Endovasc Ther UK 100,000 IU 100,000 IU/h NR 5Fr catheter continuous 36 hours (18) PTA: 47%, surgical: 22% none Oral anticoaguation, aspirin plasma fibrinogen levels, D-dimer, hemoglobin, he-matocrit, activated partial thromboplastin ICU Academic hospital NR
2003 Conrad J Vasc Surg UK 250,000 to 500,000 IU in 1-2 hours 1,000-2,000 IU/min 2,300,00 IU (250,000-14,580,000) NR pulse spray and continuous NR PTA: 27%, surgical: 22% none NR NR NR General hospital NR
2003 Tsetis J Endovasc Ther rt-PA 2x 5 mg 1-2.5 mg/h Unheated: 27.9 mg, heated: 24.3 mg 5Fr catheter continuous A: 6 hours, 12 min (0.33–13 hours), B: 2 hours, 42 min (0.75–6 hours) PTA: 79,4%, surgical: 11.8% Heparin: 500 IU/hour NR activated partial thromboplastin time, hemoglobin, platelets, and creatinine, repeat angiograms high dependecy unit vascular department Academic hospital NR
2004 Allie J Endovasc Ther TNK 10/20 mg TNK, 1,000,000 IU UK none 14.2 mg (10.6-22.6) TNK, 750,000 IU (600,000-1,200,000) UK 0,035 inch guidewire continuous A: 7.3 (3-20 hours), B: 7.8 (4-18 hours) PTA: 100%, surgical: NR Heparin 100-500 IU/hour clopidogrel, aspirin complete blood count (CBC), prothrombin time (PT), partial thromboplastin time (PTT), platelet level, and fibrinogen blood level NR General hospital NR
2004 Breukinks Ann Vasc Surg UK 250,000 IU 10,000 – 60,000 IU/h NR NR continuous NR PTA: 31%, surgical 5% Heparin NR NR ICU General hospital NR
2005 Hanover Ann Vasc Surg t-PA 0.5 U/hr NR 10.3 IU (±5.3) NR continuous 19.5 h (7.5) PTA: 39.5%, surgical: 24.6% Heparin 400-500U/hr NR baseline and and serial complete blood count, prothrombin time, partial thromboplastin time, creatinine, and fi brinogen ICU General hospital NR
2006 Plate Eur J Vasc Endovasc Surg rt-PA 0.25 mg 15 mg/h, 0.5 mg/h pulse spray: 36 mg (19-93), low dose 13 mg (1-30) endhole catheter pulse spray and continuous 1: 120 min (10-310), 2: 25 h (2-60) PTA: 60%, surgical: 8% Heparin oral anticoagultion, antiplatelet drugs heart rate, blood pressure, puncture sites, and status of the ischaemic limb were checked at least twice every hour. Blood levels of haemoglobin, platelets, prothrombin time (PK), and activated partial thromboplastin time (APTT) every 6 hrs ICU General hospital NR
2006 Tepe Radiology rt-PA, UK rt-PA 0.5 U, UK 25,000 IU rt-PA 0.5 U-1 U/h, UK: 2,000-4,000 IU/min rt-PA: 3.42 IU (±1.14), UK: 548,900 IU (±158,400) 5Fr catheter pulse spray and continuous reteplase: 200 min (60-660), UK:120 min (60-360) PTA: 86%, surgical: NR Abciximab aspirin angiography NR Academic hospital NR
2007 Wissgot J Endovasc Ther rt-PA 1 mg/h NR NR 5FR cathter continuous and EKOS 16.9 h (10.9) PTA: 40%, surgical: 8% Heparin 5,000 IU bolus plus 1,000 IU/hour clopidogrel, aspirin angiography NR General hospital NR
2007 Geier Vasa rt-PA 3 mg 2 mg/h 25.4 mg (3-60) NR continuous NR PTA:43%, surgical: 5% Heparin 500 IU/hour and 1,000I U/hour NR NR NR Academic hospital NR
2008 Disini Clin Radiol t-PA 5 mg 1 mg/h 30 mg (±2.7) 5Fr catheter continuous 24 h (4-50) PTA: 33.3%, surgical: 28.2% NR NR NR NR Academic hospital NR
2010 Han J Vasc Surg alfimeprase 0.3 mg/kg NR NR side hole catheter continuous NR PTA: NR, surgical 70% NR NR NR ICU Academic hospital NR
2011 Kuoppala J Thromb Thrombolysis alteplase 0.5-2 mg/h NR 21 mg NR continuous non bleeders 19h, bleeders 20h (16-34) PTA: 76%,surgical 4.5 % heparin NR creatinine and liver enzyme activity, and of blood hb, platelet count, APTT, PT/INR ICU Academic hospital NR
2011 Kashyap J Vasc Surg rt-PA 0.5-1 mg/h NR NR NR continuous 0-1 days (49%), 1-2 days (39%) PTA: 56%, sugical 15% NR NR NR NR General hospital NR
2011 Lokse Eur J Vasc Endovasc Surg alteplase 5 mg bolus 0.01 mg/kg/h NR NR continuous NR PTA: 72%, surgical 59% Heparin 5,000IU and systemic 3000Iu/kg/hour NR NR NR Academic hospital NR
2011 Kuhn AJR Am J Roentgenol rt-PA 2.5-5 mg NR 31.9 mg (±16.1) 4Fr catheter continuous 13.3 hours (11) PTA 41.1, surgical: 12.6% Heparin 5,000IU NR NR ICU Academic hospital NR
2012 Schrijver Cardiovasc Intervent Radiol UK none none 2,650,000 IU (850,000-7,200,00) 5Fr catheter continuous 26.5 (8.5-72) hours PTA: 67%, surgical: 10% Heparin 10,000IU/ 24 hours coumarin or antiplatelet drugs NR NR Mixed NR
2011 Koraen J Vasc Surg alteplase 0.5-2 mg/hour NR NR NR continuous 19 (1-51) hours PTA: 39 %, surgical 21% Heparin 5,000 IU NR NR NR Academic hospital NR
2011 Limtungturakul J Med Assoc Thai rt-PA 5 mg 1-2 mg/h 21-22 mg 5Fr catheter continuous NR PTA: 0/NR, surgical: 8% Heparin 600I U/hr NR angiograms NR Academic hospital NR
2011 Schrijver J Cardiovasc Surg (Torino) UK none 100,000 IU/hour NR 0,035 inch catheter continuous 21 (15-24) hours PTA: 68%, surgical: 23% Heparin 10,000IU/ 24 hours NR NR NR MIxed NR
2012 Chen Chin Med J (Engl) UK 250,000 IU 30,000-50,000 IU every 30′ 2,120,000 IU (±1,100,000) NR pulse spray and continuous NR PTA: NR, surgical: 18.2% Heparin aspirin symptoms, sigs, APTT, plasma fibrinogen, D-dimer, Hb, Ht, platelet, hepatic and renal function ICU Academic hospital NR
2012 Marder J Thromb Haemost plasmin NR NR NR multislit catheter pulse spray and continuous NR NR Heparin 500 IU/h NR angiograms, vital signs, capilarry refill, muscle and sensory function, compleed blood count NR Academic hospital NR
2013 Yuan Thorac Cardiovasc Surg rt-PA A: 20mg, B: 10mg NR NR 5Fr catheter continuous A; 75 (12), B: 79 (11) min PTA: 84.5%, surgical: 4.9% Heparin 3,000-5,000IU NR HF, RR, puncture sites, ischemic limb, complete blod count, PT, APTT, fibrinogen, creatinine ICU Academic hospital NR
2013 Falkowski Eur J Vasc Endovasc Surg rt-PA pulse spray 1 mg/minute for 15 minutes 17.5 mg/h 54.1 5Fr catheter pulse spray and continuous 2.51 hours PTA: 64%, surgical: 4% Heparin 500U/h aspirin / clopidogrel RR, HF, Sat, puncture site, status ischemic limb, hb, ht, urea and creat NR Academic hospital NR
2013 Skeik Vasc Endovascular Surg t-PA none 0,25 -2 mg/h 26.1 mg (±16.1) NR pulse spray and continuous 29.5 hours NR Heparin NR angiograms NR General hospital NR
2013 Wongwanit J Med Assoc Thai rt-PA bolus 5-15 mg 1-2 mg/h 39.8 (5-84) NR continuous 21.29 hours (2-58h) Heparin 500U/h clopidogrel NR NR Academic hospital NR
2014 Vakhitov Ann Vasc Surg alteplase 4 mg 0.5 mg/h NR NR continuous NR PTA:40%, surgical: 22% LMWH 2dd 40mg warfarin bloodtests 2dd, angiography ICU Academic hospital NR
2013 Hundt Eur.J.Radiol. UK 100,000 IU 60,000 IU/h acute PMt+T: 1,886,857 (432,691) IU, subacute PMT+T: 2,201,470 (267,560) IU, acute T: 2,502,500 IU (682,562), subacute T: 3,276,562 IU (350,111) 6Fr catheter continuous acute PMT 37.6 (8.8)hours, subacute PMT+T50 (13.6)hours, acute T 66 (13.6) hours, subacute T 65.5 (7)hours NR Heparin 400 IU/24h NR angiograms ICU Academic hospital acute PMT +T: €7,666, subacute PMT+Y: €8,650, acute T: €8,675, subacute T: €9,696
2015 Silverberg Vascular UK NR NR NR NR continuous NR NR Heparin LMWH, warfarin NR NR Academic hospital NR
2014 Grip Br J Surg rt-PA NR NR 21 mg (2-76) NR continuous 25.2 (1-93) hours PTA:NR, surgical: 20% Heparin NR NR NR Academic hospital NR
2015 Taha J Vasc Surg rt-PA bolus 2-6 mg 0.25-1 mg/h NR NR continuous 25.5 hours PTA: NR, surgical: 8.8% Heparin 500U/hour NR NR NR Academic hospital NR
2014 Ebben Eur J Vasc Endovasc Surg UK 500,000 IU low: 50,000 IU/h, high dose: 100,000 IU/h Low: 4,700,000 IU. High: 6,100,000 IU NR continuous low: 67 (4-304), high: 49 (2-171) hours NR Heparin 4,800IU/hour, 9,600 IU/hour oral anticoagulants Hb, APTT, PT, fibrinogen, trombocytes NR Academic hospital NR
2015 Lurie J Vasc Surg t-PA NR NR CDT: 36.7 mg (±15.2), CDTA 33.7 mg (±18.8) NR NR NR NR NR NR NR ICU Academic hospital trombolysis group: 9,482$. Thrombolysis plus angioplasty 9,053$
2015 Schrijver J Endovasc Ther UK bolus 250,000IU 100,000 IU/h standard: 2,800,00 IU (±1,500,000), US: 1,800,000IU (±1,000,000) 5Fr catheter continuous standard: 29.5 (3.2) hours, US: 17.7 (2) hours PTA: 60%, surgical: 17% Heparin 10,000 IU/24hr NR NR NR Mixed NR
2015 Schrijver Ann Vasc Surg UK NR 100,000 IU/h NR NR continuous NR NR Heparin 10,000 IU/24h coumarin derivates NR NR Mixed NR
1992 LeBlang J Vasc Interv Radiol UK NR 87,000 IU (50,000-150,000) 1,855,000 IU (±7,885) multiple side hole catheter, or coaxial infusion system continuous 20.4 hours (2-62) 75% percutaneous, 16% surgical heparin: side-port 100 U/h + systemic >700 U/h in 29 patients NR CBCC, platelet count, PT, APTT, fibrinogen once in 8 hours NR Private hospital NR
1992 Buckenham Eur J Vasc Surg rt-PA 3x 5 mg 0.05 mg/kg/hour 19 mg (15-26) single end hole 5.0 Fr continuous 109 min (30-240) 55% angioplasties, 15% surgical none 20,000 IU heparin intravenously in 24h NR NR General teaching hospital NR
1991 Goffette Acta Radiologica UK 75,000-375,000 UK 75,000 IU/hour NR coaxial catheter, 0.9 mm open end guidewire continuous 32 hours PTA: 33% Heparin systemic 15,000 IU/24h NR angiography NR General hospital NR
1991 Berridge Br J Surg rt-PA none 0.5 mg/h NR 4 or 5 Fr Gauge catheter straight or sidewinder type continuous 35 hours (14-64) 10% surgical (2) 250 IU heparin 1,000 U/h in 2 times 12 h Full clotting screen, platelet count, HB, whitecell count, urea, electrolyte estimation NR Academic hospital NR
1991 Parent J Cardiovasc Surg (Torino) UK 50,000-500,000 IU 20,000-80,000 IU/hour 2,525,000 IU 3-5.5 Fr polyethylelene end hole continuous 3.2 days 22.5% percutaneous, 25% surgical heparin 400-1,000 IU/h coaxial sheath/intravenously NR fibrinogen, APTT, PT, ht ICU Academic hospital average treatment costs $8,295
1991 McNamara Circulation UK 4000 IU/min 60,000-240,000 IU/hour NR transcatheter continuous 18 hours 22.2% surgical. 50% PTA (31 only PTA, 5 PTA and surgical) heparine 1,000 IU/h intravenous (97%) NR aPTT, fibrinogen, hemoglobin, platelets, fibrin degradation products, euglobulin lysis, and creatinine. Intensive care Academic hospital NR
1991 Sullivan Circulation UK 30,000-250,000 IU 60,000-240,000 IU/hour NR NR continuous NR 18,9 % surgical NR NR prothrombin time, activated partial thromboplastin time, hemo- globin, hematocrit, and platelets Intensive care or radiology department Academic hospital NR
1991 Cragg Radiology UK 50,000 IU or 250,000 IU 50,000U/hr or 125,000/hour 2,299,400 U 5 Fr infusion catheter continuous 20.4 hours 33,3 %PTA, 41,2 % surgical (10 bypass grafts, 1 endarterectomy, 10 bypass revision, 6 redo bypass) heparine NR fibrinogen, hemoglobine, aPTT, platelet count,mental status NR Academic hospital NR
1991 Gaston Kans Med UK NR 60,000-120,000U/hour NR 5 Fr straight non-side port cathether continuous NR 13% surgical (embolectomie), PTA heparine 5,000 IU + systemic 1,000 IU/h NR vital signs, doppler pulses and puncture sites Intensive care General teaching hospital NR
1990 Meyerovitz Radiology rt-PA, UK bolus rt-PA: 10mg, UK: 60,000 IU rt-PA 5 mg/hour, UK: 60,000-240,000 IU/hour NR NR continuous NR PTA: 25%, surgical: 53% NR NR NR NR Academic hospital NR